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MDA levels showed negative associations with stress and workload. Nurses experience high levels of occupational stress and workload. Conclusion. Biomarkers such as SOD, TAC and MDA are the most important predictors of work stress and overwork in this study.Flight risk assessment tools (FRATs) aid pilots in evaluating risk arising from the flight environment. Current FRATs are subjective, based on linear analyses and subject-matter expert interpretation of flight factor/risk relationships. However, a 'flight system' is complex with non-