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In this study, five polysaccharides had been prepared from Sargassumfusiforme and their particular effects on HFD-induced fasting hypoglycemia and instinct microbiota dysbiosis were investigated. The outcomes indicated that C57BL/6J male mice fed an HFD for 4 weeks developed extreme hypoglycemia and four Sargassumfusiforme polysaccharides (SFPs), consisting of Sf-2, Sf-3, Sf-3-1, and Sf-A, notably prevented early fasting hypoglycemia without inducing hyperglycemia. Sf-1 and
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