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mm Hg, because these recommendations differ from some other guidelines.Background Vancomycin is associated with nephrotoxicity and the mechanism may in part be related to oxidative stress. In vitro and preclinical studies suggest melatonin supplementation decreases oxidative stress. The objective of this study was to evaluate concomitant use of melatonin and vancomycin and the incidence of acute kidney injury (AKI). Methods We performed a retrospective cohort study at a large community medical center. All consecutive patients admitted to