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he clinical value of detailed metabolic and genetic profiling of patients with excessive alcohol use. Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer cohort. Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant d