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Only cyclosporine use and calcineurin inhibitor (CNI) withdrawal were strongly associated with DSA and rejection. With a median follow-up of 8.9 years, GF occurred in 87 patients (29.0%). After adjustment for recipient and donor age, CNI trough level, DSA, and rejection, MNA was not associated with GF. The only parameters associated with GF were DSA occurrence, and acute rejection. Prospective serial monitoring of MNA using the Morisky scale does not predict DSA occurrence, rejection or GF in KTRs. In contrast, cyclosporine and CNI withdr