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Supporting in vitro experiments showed that M2 is reduced to M16 anaerobically in fecal homogenate and M16 is oxidized in the liver by aldehyde oxidase (AO) to M2. LY3202626 also showed a potential to form a reactive sulfenic acid intermediate. A portion of plasma radioactivity was unextractable and presumably bound covalently to plasma proteins. In vitro incubation of LY3202626 in human liver microsomes in the presence of NADPH with dimedone as a trapping agent implicated the formation of the proposed sulfenic acid intermediate.This wo
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