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Especially, this ionic skin patch can recognize temperature change signals precisely either in broad or extremely narrow temperature range. This smart skin patch can even recognize the pressure and temperature signals in real time and differentiate the signals simultaneously.In this review, we discussed about the synthetic developments in the field of Fe-catalysis for the formation of - bonds through the coupling of alkynes and alcohols, for the period of 13 years (2008-202. These strategies fulfil important Green Chemistry principles,