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We found that M 2 sometimes had inflated Type I error rates, M 2 * always had little power, and C 2 lacked power under some conditions. M 2 and C 2 may provide complementary and valuable information regarding model fit. Peripheral neuropathic pain is a disabling condition for patients and a challenge for physicians. Although many drugs have been assessed in scientific studies, few have demonstrated clear clinical efficacy against neuropathic pain. Moreover, the paucity of data regarding their safety raises the question of the benefit-risk r