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Moreover, our method achieved an improved AUROC of 0.852 by further expanding the training dataset. We believe that our method can be a useful supplement to the existing methods, as it provides an alternative way to estimate lncRNA-protein interactions in a heterogeneous network without direct prior knowledge. All data and codes of this work can be downloaded from GitHub (https//github.com/zyk2118216069/LncRNA-protein-interactions-prediction). Copyright © 2020 Zhou, Shen, Yu, Luo, Gao and Du.The "large p small n" problem has posed a si