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Divergence from the age-appropriate SCN was related to reduced EF performance and an increase in behaviours related to executive dysfunctions. The DDI measure showed predictive value with regard to executive functions, highlighting that early imaging can assist in prognosis for cognition. In the present longitudinal study, we investigated the joint effect of early family factors and long-term vocabulary development on the structure of reading-related white matter pathways in adolescents. Seventy-nine children participated in this study.