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Intramolecular energy flow (also known as intramolecular vibrational redistribution or IVR) is often assumed in Rice-Ramsperger-Kassel-Marcus, transition state, collisional energy transfer, and other rate calculations not to be an impediment to reaction. In contrast, experimental spectroscopy, computational results, and models based on Anderson localization have shown that ergodicity is achieved rather slowly during molecular energy flow. The statistical assumption in rate theories might easily fail due to quantum localization. Here, we d