https://www.selleckchem.com/pr....oducts/elexacaftor.h
At progenitor stage, comparison of the two populations showed downregulation of pancreatic epithelial genes and upregulation of neuronal development genes in PDX1 /NKX6.1 cells in comparison to the PDX1 /NKX6.1 cells. Interestingly, on further differentiation, PDX1 /NKX6.1 cells generated mono-hormonal insulin cells and activated pancreatic key genes, such as PDX1. The transcriptome profile of PDX1 /NKX6.1 -derived beta (3D-beta) was closely similar to those of human pancreatic islets and purified hPSC-derived beta cells. Also, the
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