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72±112%, respectively, p less then 0.001), during the Rest Week (98±66% vs. 42±79%, p less then 0.001) and at Post3 (115±82% vs. 28±78%, p=0.003). Glycogen content was reduced in both fiber types; but most pronounced in type I, which did not recover until the Rest Week (-15-29%, p≤0.001). Intramuscular macrophage numbers were increased by ~65% post-intervention, but no changes were observed in muscle neutrophils. We conclude that high-frequency BFRRE with sets performed till failure stresses both fiber types, with type I fibers being most affected.Modulatio