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09 to 9.32 fL, P = 0,004). CONCLUSION MPV can be used as a predictor of early response to the first line treatment in newly diagnosed adult primary ITP patients.BACKGROUND Heroin can be detected and quantified by certain analytical methods; however, forensic professionals and criminal laboratories study for cheaper and faster detection tools. Surface-enhanced Raman spectroscopy rise as a possible alternative tool with their widening application spectra. There are few studies regarding Raman and SERS spectra of heroin and its metabolites,