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Many medicines currently in use had been approved centered on clinical studies carried out on men, so women could be overmedicated. We determined whether intercourse variations in medicine pharmacokinetics, PKs, predict intercourse differences in ADRs. Methods lookups of this ISI Web of Science and PubMed databases were performed with combinations for the terms drugs, intercourse or sex, pharmacokinetics, pharmacodynamics, medicine safety, drug dosage, and undesirable drug effect, which yielded over 5000 articles with significant over