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Despite advances in healthcare technology, the early detection biomarker and treatment remain one of the biggest challenges in humanity. Thus, developing a biosensor for timely diagnosis is well-justified to improve the prospect of remission of cancer patients. Surface plasmon resonance (SPR), a biosensor, is of interest that monitors many cancer biomarkers with high sensitivity and rapidity. For various cancers, nanoparticle (NP)-based targeted drug/gene delivery has been widely employed as it directs mainly the receptors expressed speci