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The prognosis of the patients with ≥2 minor risk factors was significantly worse than that of the patients with 0 or 1 minor risk factor(s) (OS 91.6% vs. 64.5%, respectively, p 0.01; CSS 98.9% vs. 78.9%, respectively, p 0.001; and RFS 81.2% vs. 58.5%, respectively p 0.05). Grade 4 invasion and perineural invasion might be significant minor risk factors in OSCC patients. The presence of ≥2 minor risk factors might be a predictor of a poor prognosis in OSCC patients. Grade 4 invasion and perineural invasion m