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Recently, several medicines, such as for instance esmolol and ivabradine, have now been turned out to be advantageous in hour control, but their general effect on cardiac functions needs more research. The aim of this study would be to learn the results for the two medications on heart purpose in a protocol of polymicrobial septic shock and resuscitation. Twelve pigs had been divided in to three experimental teams the esmolol-treated group (n=4), the ivabradine-treated group (n=5) in addition to control gro