https://www.selleckchem.com/pr....oducts/brigimadlin.h
In this study, we investigated sex-specific effects of acute exposure to trimethyltin, a known neurotoxicant on metabolic steroids. We administered intraperitoneally 2.3 mg/kg trimethyltin to 4-week-old male mice and measured the levels of metabolic steroids 24 h after treatment. We also measured mRNA and protein levels of cytochrome P450 1B1 using real-time polymerase chain reaction and western blotting. Cortisol levels in the cortex increased in both sexes following acute trimethyltin exposure. The estradiol levels decreased, and
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