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Purpose Colon cancer-associated transcript 1 (CCAT1) was identified as an oncogenic long non-coding RNA (lncRNA) in a variety of cancers. However, there was a lack of understanding of the mechanism by which CCAT1 conferred cisplatin (also known as DDP) resistance in ovarian cancer cells. Materials and Methods Cell viability of A2780, SKOV3, A2780/DDP and SKOV3/DDP cells upon cisplatin treatment was monitored by MTT assay. qRT-PCR detected the expression levels of CCAT1 and miR-454. The effect of sh-CCAT1 on cisplatin response was invest