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How Does Medication For ADHD Work? The most common medications that doctors prescribe to treat ADHD work by increasing levels of dopamine and norepinephrine within the brain. They are available in short-acting as well as extended-release formulations. Medications affect everyone differently, so it may take some time to find the right dosage and medication for your child or yourself. In addition to medications lifestyle changes can also help improve symptoms. Methylphenidate Methylphenidate, a central nervous stimulant, is used to treat ADH