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Objective To research the protective role of alprostadil on aortic dissection. Methods 26 C57BL6 male mice had been split into control group (regular drinking water, n=13) and design group (1 g·kg-1·d-1 BAPN via drinking water, n=13). On time 14, mRNA expression of inflammatory-related genetics along with EP receptor people had been detected by RT-PCR (n=6 each) and EP4 necessary protein amounts were dependant on Western blot (n=7 each). Another 88 mice were divided in to 3 team