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ciated with reduced mortality and code rates. We recognise that these gains vary depending on resource availability and efferent response systems.PROSPERO registration CRD42021269579. Healthcare systems that implemented PEWS were associated with reduced mortality and code rates. We recognise that these gains vary depending on resource availability and efferent response systems.PROSPERO registration CRD42021269579.Organ damage and pathological disease states lead to the rapid release of microRNAs (miRNAs), a class of endogenous small n