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This disruption is associated with an inhibition of inflammatory interleukin 17 secretion. CONCLUSION The data highlights the major involvement of Th17 immune cells in the biological effects of an RWE. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.BACKGROUND Similar to chronic wounds, skin aging is characterized by dysfunction of key cellular regulatory pathways. The hypoxia-inducible factor-1 alpha (HIF-1α) pathway was linked to both conditions. Recent evidence suggests that modulating this pathway can rejuvenate aged fibroblas
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