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ADHD Treatment For Adults - Stimulant Medication Stimulant medicines like methylphenidate or dextroamphetamine are typically considered the as the first line treatment for adults with ADHD. These medications balance and increase levels of brain chemicals known as neurotransmitters. Antidepressants and nonstimulant medications like atomoxetine are often prescribed when stimulants are not suitable for the patient due to health problems or adverse effects. These medications are slower acting