https://www.selleckchem.com/pr....oducts/jnj-42226314.
Studies have confirmed that tumorigenesis is related to an imbalance of polyamine metabolism and over-expression of oncogenes resulting in the up-regulation of ornithine decarboxylase (ODC, the first rate-limiting enzyme for regulating intracellular polyamines biosynthesis), which has become a target for anti-tumor therapy. In this study, an ornithine derivative, N -(2-[ F]fluoropropionyl) ornithine (N -[ F]FPO), has been prepared and its potential utility for tumor PET imaging evaluated. N -[ F]FPO was successfully prepared via a
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