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or not to prescribe prophylactic AEDs (Level U). Longitudinal measurement of tumor burden with MRI is an essential component of response assessment in pediatric brain tumors. We developed a fully automated pipeline for the segmentation of tumors in pediatric high-grade gliomas, medulloblastomas, and leptomeningeal seeding tumors. We further developed an algorithm for automatic 2D and volumetric size measurement of tumors. A preoperative and postoperative cohort were randomly split into training and testing sets in a 41 ratio. A 3D U-Net neu
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