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The predicted AUASI during follow-up for robust men at baseline exhibited a gradient. Specifically, it was 42 (95% CI 39, 45) for zero frailty criteria, 46 (95% CI 43, 49) for one criterion, and increased non-linearly to 112 (95% CI 98, 126) for those meeting five criteria. Over time, a higher level of phenotypic frailty in older men correlated with non-linear increases in the severity of lower urinary tract symptoms (LUTS), irrespective of age and comorbidity factors. A shared underlying mechanism, linking LUTS and frailty, is suggested by the results, but not cu