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PCV-10 crossprotection against 19A was significant in children ≤5 years with ≥1 dose (82.2% and 71%). Neither PCVs were found effective against serotype 3. PCV-13 was effective against AOM (86%; 95% self-confidence period [CI] 61 to 94). PCV-10 had been effective against medically defined (26.9%; 95% CI 5.9 to 43.3) and bacteriologically confirmed AOM (43.3%; 95% CI 1.7 to 67.3). LIMITATIONS Because associated with big heterogeneity in studies, a meta-analysis for pooled quotes had not be