https://www.selleckchem.com/pr....oducts/iacs-13909.ht
GBP5, one of the most differentially-expressed genes between IFN-α14- and -α2-treated liver cells, was identified as a new HBV restriction factor. A strong IFN-α-IFNAR1 receptor subunit interaction determines the anti-HBV activity of IFN-α. The in vivo anti-HBV activity of IFN-α14 and treatment-related transcriptional patterns were further confirmed, and little adverse effect was observed. CONCLUSION A concerted IFN-α and -γ response in liver, which could be efficiently elicited by IFN-α subtype 14, is associated with potent HBV supp
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