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63; 95% CI, 0.38-0.87; P = 0.00. The complete and partial tumor RRs were also increased significantly in the HAIC as palliative treatment group (RR = 2.09; 95% CI, 1.36-3.22; P = 0.001) and as adjuvant treatment group compared with SC group (RR = 2.14; 95% CI, 1.40-3.26; P = 0.00. However, PFS did not differ significantly between the HAIC and SC groups (P 0.05). Meta-regression analysis showed potential covariates did not influence on the association between HAIC and OS outcomes (P 0.05). The results of the present stu