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Results Effect sizes from 12 studies, sampling 4673 adolescents, were synthesized. Sexual health interventions improved abstinence (d = 0.15, 95% CI 0.02 to 0.28), condom use (d = 0.44, 95% CI 0.18 to 0.7, number of sex partners (d = -0.19, 95% CI -0.37 to -0.001), and sexual health knowledge (d = 0.40, 95% CI 0.10 to 0.7, compared with control conditions. Effects were consistent across a number of demographic and clinical characteristics, although culturally tailored interventions produced greater change in condom use than nontail