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How Does ADHD Medication Work? When a neuron sends a message to another, it makes use of neurotransmitters or chemicals. They must traverse a small gap, which is known as a synapse. Certain ADHD medications help in the passing along of these messages more effective. They can help neurons release more neurotransmitters, or slow down the reuptake process (called Reuptake inhibitors). Doctors start people with ADHD with a small dose of medication and observe their responses. They alter the dosage a