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Meanwhile, system topology evaluation suggests that the ICSs during EMT act as the signaling in cellular interaction under different circumstances. Interestingly, our evaluation of a mouse epidermis squamous mobile carcinoma dataset also proposes whatever the significant discrepancy in tangible genes between in vitro and in vivo EMT systems, the ICSs play principal part in the TGF-β signaling crosstalk. Overall, our strategy reveals the multiscale mechanisms coupling cell-cell communications and gene-gene laws ac
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