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Adult ADHD and Comorbid Disorders Many people with ADHD also suffer from comorbid disorders like major depression (Kessler and colleagues, 2006). Many people who suffer from depression are not able to respond well to medication and could be able to benefit from therapy. Medications that most effectively improve core symptoms of ADHD seem to boost and balance levels of certain brain chemicals called neurotransmitters. Stimulants such as methylphenidate and amphetamine are frequently prescrib