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In general, our findings demonstrated that using UiO-66-NH2 might be a promising strategy to immobilize enzyme and produce effective biocatalyst with high activity and stereo-selectivity.Biocompatible nanocomposites (NCs) with antibacterial activity containing organic matrix and inorganic nanoparticles (NPs) are vital for providing a suitable substrate for hydroxyapatite (HA) formation. Therefore, we fabricated a series of biocompatible NCs of chitosan (CS) and tragacanth gum (TG) and different percentages of ZnO NPs and ZnO@Ag NPs as f