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Therefore, the pdx1 -/- mutant signifies a novel design to examine mechanisms of hyperglycemia-induced retinopathy wherein considerable proangiogenic modifications in blood vessel morphology and metabolic alterations underlie the vascular phenotype. © 2020 by the United states Diabetes Association.Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin within the endoplasmic reticulum (ER) drive the molecular pathog