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PURPOSE Clinical use of dedicated breast CT (bCT) requires relatively short scan times necessitating systems with high frame rates. This in turn impacts the x-ray tube operating range. We characterize the effects of tube voltage, beam filtration, dose, and object size on contrast and noise properties related to soft tissue and iodine contrast agents as a way to optimize imaging protocols for soft-tissue and iodine contrast at high frame rates. METHODS This study design uses the signal-difference-to-noise ratio (SDNR), noise-equivalent q