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In the total cohort, significant differences were observed for CD8+ , CD20+ , and CD204+ cells in tumor islets, and CD8+ , CD20+ , FOXP3+ cells, the CD8/CD204 ratio and the CD20/CD204 ratio in the stroma, indicating their prognostic effect. The prognosis effect of the PD-L1 expression in tumor cells could not be established, possibly associated with intratumoral heterogeneity. CD8, CD20, and CD204 positive TIICs in stroma were identified as possible better prognostic biomarkers, considering the heterogeneity of other biomarkers. This s
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