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Longitudinal modification of P-tau181 had been highly associated with gray matter loss when you look at the complete test and with Aβ measures in CU individuals. P-tau181 detected AD at MCI and dementia stages and had been highly connected with intellectual decline and grey matter reduction. These results highlight the potential worth of plasma P-tau181 as a non-invasive and economical diagnostic and prognostic biomarker in advertising.P-tau181 detected advertising