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SSc with a decreased symptom burden at baseline exhibited improved outcomes. Copyright © Rezus et al.Type 2 taste receptor 10 (TAS2R1, belonging to the TAS2R family of bitter receptors, is widely expressed in extra-oral tissues. However, its biological roles beyond bitterness sensing in the tongue have remained largely elusive. The present study aimed to perform a positive co-expression analysis using 60,000 Affymetrix expression arrays and 5,000 The Cancer Genome Atlas datasets to uncover such roles. Based on the functional enrichment