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Day-to-day GEN management substantially enhanced cognitive function when you look at the ORT and MWM examinations. GEN therapy also inhibited SPS-induced decreases in serotonin (5-HT) levels within the medial prefrontal cortex and hippocampus. These increased 5-HT levels in response to GEN therapy might be partially caused by the proportion of 5-hydroxyindoleacetic acid/5-HT in the hippocampus. Our conclusions suggest that GEN somewhat attenuates SPS-induced memory deficits in rats and may express a h
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