https://www.selleckchem.com/products/ml323.html
Low airway surface pH is associated with many airway diseases, impairs antimicrobial host defense, and worsens airway inflammation. Inhaled Optate is designed to safely raise airway surface pH and is well tolerated in humans. Raising intracellular pH partially prevents activation of SARS-CoV-2 in primary normal human airway epithelial (NHAE) cells, decreasing viral replication by several mechanisms. We grew primary NHAE cells from healthy subjects, infected them with SARS-CoV-2 (isolate USA-WA1/202, and used clinical Optate at concentra
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