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Medical biomarkers and targeted treatments for this disease remain elusive, therefore chemotherapy has been the standard of take care of early and metastatic TNBC. Our current conclusions put ErbB-2 in an unanticipated scenario the nucleus of TNBC (NErbB-2). Our research on ErbB-2 alternative splicing events, making use of a PCR-sequencing approach along with an RNA interference method, disclosed that TNBC cells present either the canonical (wild-type) ErbB-2, encoded by transc