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In the adjusted analysis, the following factors were associated with worse healthcare utilization outcomes for cannabis use disorder hospitalizations older age; Deyo-Charlson index score of 2 or higher; male sex; insurance payer other than private; higher income; hospital region; an urban hospital; and a medium to large hospital bed size. Conclusions Rising hospitalization rate with cannabis use disorder from 1998 to 2014 is concerning. Our study identified independent variables associated with a higher risk of poor utilization outcomes