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, the "hybrid epithelial-mesenchymal (hybrid E/M)" condition, provides a potential description for many conflicting results. Appearance of hybrid E/M phenotype offers a more synthetic status for disease cells to adapt the stressful environment for continuing metastasis. In this article, we examine the biological significance of the powerful changes amongst the epithelial therefore the mesenchymal states. The regulating systems encompassing the translational, post-translational, and epi