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How Does ADHD Medication Work? The drugs help reduce ADHD symptoms by increasing the levels of dopamine and Noradrenaline, which are chemicals that transmit messages between brain cells. The most commonly prescribed stimulants are methylphenidate and the atomoxetine. Finding the right dose and dosage is often a trial and error process. Communication that is honest and open with your doctor is crucial. Stimulants The stimulant medications prescribed to treat ADHD increase levels o