https://www.selleckchem.com/pr....oducts/PD-0332991.ht
44 days (95% CI -3.79 to 0.91)) but did in cohort studies (MD -1.52 days (95% CI -2.71 to -0.34)). No statistically significant benefit of lighter sedation was identified in RCTs. In cohort studies, lighter sedation improved time to extubation, intensive care and hospital length of stay and ventilator-associated pneumonia. We found no significant effects for hospital mortality, delirium or adverse events. Evidence of benefit from lighter sedation is limited, with inconsistency between observational and randomised studies. Positive ef
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