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Medication For ADHD - What Are the Side Effects? Many people who suffer from ADHD have their symptoms improved by taking medication. Every person's reaction to medication is different, and the side effects can be problematic. Methylphenidate is a stimulant. It increases the levels of a chemical in the brain that helps regulate the behavior and focus. Stimulant medications Stimulant medications improve attention and concentration for 70% to 80% children and adults t