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How Does ADHD Medication Work? ADHD is treated with stimulants. They regulate the levels of neurotransmitters (two brain chemicals) that transmit messages between neurons to improve attention and decrease excessive hyperactivity. 20 % of people are not sensitive to stimulants such as methylphenidate or amphetamine. This may be due to the body's chemistry or other drugs they are taking. What are the signs of ADHD? If you suspect that your child has ADHD begin by visiting their doctor. They will perfor